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本研究的目的主要是观察异丙酚在全麻诱导插管期间对心血管系统的影响，并与硫喷妥钠进行临床比较。择期手术病人２０例，随机分为二组，即异丙酚组（Ｐ组）和硫喷妥钠组（Ｔ组），每组各１０例。诱导方法为静注异丙酚２．５ｍｇ／ｋｇ或硫喷妥钠６～７ｍｇ／ｋｇ和琥珀酰胆碱１．５～２．０ｍｇ／ｋｇ后气管插管。应用ＢｏＭｅｄＮＣＣＯＭ３－Ｒ７无创心功能监测仪分别在诱导前、诱导后、插管后即刻及插管后１、５ｍｉｎ测定血流动力学参数的变化。结果表明，诱导后Ｐ组的血压和ＲＰＰ明显降低而ＨＲ稍减慢，其血压下降的幅度比Ｔ组显著，而静注硫喷妥钠后ＨＲ明显增快，ＲＰＰ反而增高，说明异丙酚可能减少心肌的耗氧量。在插管后即刻Ｐ组的血压、ＲＰＰ和ＨＲ上升幅度比Ｔ组小，说明应用异丙酚时插管刺激引起的高血压反应比硫喷妥钠弱。上述表明异丙酚不失为一种良好的全麻诱导药，在老年人和其他方面的应用仍有待研究。
The purpose of this study was to observe the effects of propofol on cardiovascular system during intubation induced by general anesthesia and to compare it with thiopental. Elective surgery in 20 patients were randomly divided into two groups, namely, propofol group (P group) and thiopental group (T group), 10 cases in each group. Induction of intravenous propofol 2.5mg / kg or thiopental 6 ~ 7mg / kg and succinylcholine 1.5 ~ 2.0mg / kg after tracheal intubation. The changes of hemodynamic parameters were measured before induction, after induction, immediately after intubation and 1,5 minutes after intubation using BoMedNCCOM3-R7 non-invasive heart function monitor. The results showed that after induction, the blood pressure and RPP of P group decreased obviously and HR slightly decreased, the amplitude of blood pressure decreased significantly more than that of T group, while the HR of intravenous injection of thiopental was significantly increased and RPP increased, indicating that propofol May reduce myocardial oxygen consumption. P group immediately after intubation blood pressure, RPP and HR increased less than the T group, indicating that the use of propofol intubation stimulation caused by hypertension than thiopental sodium. The above shows that propofol can be a good general anesthesia inducer, in the elderly and other aspects of the application remains to be studied.