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目的:调查妇女生殖道高危型人乳头瘤病毒(Human papillomavirus,HPV)感染状况,研究高危型HPV感染与宫颈癌及癌前病变的关系。方法:应用第二代杂交捕获(hybrid capture,HC-Ⅱ)实验对30~49岁的已婚妇女进行高危型HPV DNA检测,采用多因素的非条件Logistic回归模型分析HPV感染与宫颈癌及宫颈上皮内病变(CIN)的关系。结果:调查人群高危型HPV DNA总检出率为18.7%,与正常组相比检出率随病变程度加重呈趋势性增高(χ2=444.04,P<0.001)。各年龄组宫颈HPV DNA的检出率几乎一样,无显著性差异(χ2=10.25,P>0.001)。非条件Logistic回归分析显示,HPV感染与宫颈上皮内高度病变(CINⅡ)及癌症的发生高度相关(OR=121.1)。结论:生殖道高危型HPV感染是当地宫颈癌及宫颈上皮内瘤变流行的主要危险因素,提示宫颈癌的防治重点应放在防止HPV感染、对HPV感染的筛查和密切监测已感染高危型HPV的对象。
Objective: To investigate the prevalence of human papillomavirus (HPV) in the genital tract of women and to study the relationship between high-risk HPV infection and cervical cancer and precancerous lesions. Methods: High-risk HPV DNA was detected in second-generation hybrid capture (HC-Ⅱ) test in 30-49-year-old married women. Multivariate non-conditional Logistic regression model was used to analyze the relationship between HPV infection and cervical cancer and cervix The relationship between intraepithelial lesions (CIN). Results: The detection rate of high-risk HPV DNA in the survey population was 18.7%. Compared with the normal control group, the detection rate increased with the severity of the disease (χ2 = 444.04, P <0.001). The detection rate of cervical HPV DNA in each age group was almost the same, with no significant difference (χ2 = 10.25, P> 0.001). Non-conditional Logistic regression analysis showed that HPV infection was highly correlated with CINⅡ and cancer (OR = 121.1). Conclusion: The high risk genital HPV infection is the main risk factor of local cervical cancer and cervical intraepithelial neoplasia, suggesting that the prevention and treatment of cervical cancer should focus on preventing HPV infection, screening for HPV infection and closely monitoring the high risk type The object of HPV.