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目的:观察氯沙坦对两肾一夹高血压大鼠(2K1C)肠系膜动脉血管重构的影响。方法:建立2K1C高血压大鼠模型。夹尾法测定大鼠血压。在实验结束时,使用磷酸盐缓冲溶液对大鼠进行灌注,再用4%多聚甲醛在体灌注,取肠系膜动脉,10%福尔马林保存进行形态学分析。结果:肾动脉狭窄大鼠较假手术大鼠血压明显升高(P<0.01),在10周末给予氯沙坦干预,能剂量依赖性地显著降低血压(P<0.01)。给予氯沙坦干预4周,大鼠肠系膜动脉血管重构参数,即中膜面积/管腔面积比值和中膜厚度/管腔直径比值显著降低。结论:氯沙坦能够逆转肾性高血压大鼠肠系膜动脉血管重构。
Objective: To observe the effect of losartan on the remodeling of mesenteric artery in 2K1C rats. Methods: To establish 2K1C hypertensive rat model. Rat tail blood pressure measurement method. At the end of the experiment, rats were perfused with phosphate buffered saline and then morphologically analyzed by 4% paraformaldehyde in vivo perfusion with mesenteric artery and 10% formalin preservation. Results: Compared with the sham operated rats, the stenosis of renal artery was significantly increased (P <0.01). Losartan intervention at the end of 10 weeks significantly decreased the blood pressure in a dose-dependent manner (P <0.01). At 4 weeks after intervention with losartan, the mesenteric arterial remodeling parameters, ie, the ratio of medial area to lumen area, and the ratio of medial thickness to lumen diameter were significantly decreased. Conclusion: Losartan can reverse the remodeling of mesenteric artery in renal hypertensive rats.