Whelan和Goldwasser等1984年首次报道了3例静注大剂量甘露醇(400～900g/d)引起的急性肾功能衰竭(ARF)。近年来有关甘露醇诱发ARF的报道日趋增多,并已引起人们的重视。现就静注甘露醇引起ARF的临床表现、发病机理及防治等问题作一概述。 1 临床表现甘露醇致ARF的准确发生率尚无报道。一般认为与静注甘露醇的剂量及患者基础肾功能和易致肾损害 Whelan and Goldwasser et al. Reported for the first time in 1984 three acute renal failure (ARF) caused by intravenous injection of large doses of mannitol (400-900 g / d). In recent years, reports of mannitol-induced ARF have been increasing and have drawn people’s attention. Now intravenous injection of mannitol caused ARF clinical manifestations, pathogenesis and prevention and treatment of other issues to be outlined. 1 Clinical manifestations Mannitol-induced ARF exact incidence has not been reported. It is generally believed that intravenous mannitol and the patient’s basic renal function and renal damage