论文部分内容阅读
为研究尿毒症及血液透析对血清一氧化氮 (NO)浓度的影响及其临床意义 ,应用硝酸盐还原酶法检测了 1 0例尿毒症未透析患者、1 4例维持性血液透析患者透析前后及 1 0例正常对照者血清NO浓度。结果 :尿毒症未透析及血透患者NO水平均较正常对照显著升高 (P <0 .0 5) ,且尿毒症未透析患者血NO浓度与肿瘤坏死因子 α水平呈显著性正相关 (r =0 .858,P <0 .0 0 1 )。血液透析后NO浓度较透析前显著降低 (P <0 .0 5) ,但透析间期又会导致其蓄积。结果提示 :NO的蓄积对尿毒症的临床表现可能有一定影响。
To investigate the effect of uremia and hemodialysis on serum nitric oxide (NO) concentration and its clinical significance, nitrate reductase assay was used to detect 10 cases of uremic patients without dialysis, 14 cases of maintenance hemodialysis patients before and after dialysis And serum NO levels in 10 normal controls. Results: The levels of NO in patients without uremia and those in hemodialysis patients were significantly higher than those in controls (P <0.05), and there was a significant positive correlation between serum NO levels and tumor necrosis factor-α levels in uremic patients without dialysis (r = 0 .858, P <0. 001). After hemodialysis NO concentration was significantly lower than before dialysis (P <0. 05), but the dialysis interval will lead to its accumulation. The results suggest that: the accumulation of NO on the clinical manifestations of uremia may have some impact.