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目的定量分析白内障患者术前不同时间应用加替沙星(抗生素)滴眼液后房水中的药物浓度。方法随机选取白内障患者36例,分为4组。各组患者均在术前3天内,于手术的眼局部应用加替沙星滴眼液,每日4次,每次1滴。手术当日,各组分别于术前15、30、60、120min用加替沙星滴眼液1次;于术中取房水0.1mL,用高效液相色谱-串联质谱法测量房水中的药物浓度。结果4组房水中药物浓度分别为(0.15±0.29)、(0.33±0.22)、(0.31±0.19)、(0.74±0.32)μg.mL-1。结论加替沙星滴眼液具有良好的角膜穿透性,局部应用能够在房水中获得有效的药物浓度;于术前120min用药时,房水药物浓度最高。
Objective To quantitatively analyze the drug concentration of aqueous humor in aqueous humor of patients with cataract treated with gatifloxacin (antibiotic) eye drops at different time before surgery. Methods A total of 36 patients with cataract were randomly selected and divided into 4 groups. Each group of patients were treated with gatifloxacin eye drops in the eye of the operation within 3 days before operation, 1 drop each time for 4 times a day. On the day of surgery, gatifloxacin eye drops were taken at 15, 30, 60 and 120 minutes before operation respectively. 0.1 ml of aqueous humor was taken during operation and the contents of the aqueous humor were measured by HPLC-MS / MS concentration. Results The aqueous concentrations in the four groups were (0.15 ± 0.29), (0.33 ± 0.22), (0.31 ± 0.19) and (0.74 ± 0.32) μg.mL-1, respectively. Conclusion Gatifloxacin eye drops have good penetrating cornea, and topical application can obtain effective drug concentration in aqueous humor. At 120 minutes before operation, the aqueous humor concentration is the highest.