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近年来研究发现,p16是细胞周期调控过程中一个重要的抑癌基因,其缺失或失活可导致肿瘤的发生.我们采用免疫组化 S-P 法检测大肠癌中 p16,pRb 的表达情况,旨在探讨二者在大肠癌中发生发展中的作用以及它们之间的相互关系.1 材料和方法1.1 材料大肠癌67例,癌旁粘膜40例和正常粘膜40例取自我院外科1998-07/1999-09手术切除的标本.其中男39例,女28例,年龄27岁～81岁.67例大肠癌中,左半结肠癌18例,右半结肠癌11例,直肠癌38例.巨检溃疡型52例,隆起型13例,浸润型2例.所有病例术前未经任何化疗和放疗,术后
In recent years, it has been found that p16 is an important tumor suppressor gene in the process of cell cycle regulation, and its deletion or inactivation can lead to tumorigenesis.We used immunohistochemical SP method to detect the expression of p16 and pRb in colorectal cancer, To explore the role of both in the occurrence and development of colorectal cancer and their relationship.1 Materials and Methods 1.1 Materials Colorectal cancer in 67 cases, adjacent mucosa in 40 cases and normal mucosa in 40 cases taken from our hospital surgery 1998-07 / 1999-09 Surgical resection specimens, including 39 males and 28 females, aged 27 to 81. 67 cases of colorectal cancer, 18 cases of left colon cancer, right colon cancer in 11 cases, rectal cancer in 38 cases. Thirty-two cases of ulcer type, 13 cases of bulging type and 2 cases of infiltrative type were collected.All cases were given without chemotherapy and radiotherapy before operation,