以香草醛和取代扁桃酸为原料,经多步反应合成了N-取代苯乙基扁桃酰胺,在对甲苯磺酸催化下,和醛脱水关环,得到一系列新颖的3-取代苯乙基-5-芳基噁唑-4-酮类化合物和N-扁桃酰四氢异喹啉类化合物.所有化合物通过红外光谱、核磁共振氢谱、元素分析和高分辨质谱对其结构进行表征,并对其构效关系进行了讨论. Using vanillin and substituted mandelic acid as raw materials, N-substituted phenethylmandelic acid amide was synthesized by multi-step reaction. After the p-toluenesulfonic acid was catalyzed, the aldehyde was dehydrated to form a series of novel 3-substituted phenethyl -5-aryl oxazol-4-ones and N-mandelic tetrahydroisoquinolines, all of which are characterized by IR, 1H NMR, elemental analysis and high resolution mass spectrometry and The structure-activity relationship is discussed.