【摘 要】
：
Blood-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain diseases.However,during the onset and progression of
【机 构】
：
Jiangsu Key Laboratory of Neuropsychiatric Diseases Research,College of Pharmaceutical Sciences,Sooc
论文部分内容阅读
Blood-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain diseases.However,during the onset and progression of brain diseases,BBB alterations evolve inevitably.In this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer\'s disease,Par-kinson\'s disease,epilepsy,stroke,traumatic brain injury and brain tumor.The advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.
其他文献
Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies.Immune cell modulation through the admin-istration of drugs,proteins,and cells can enhance antitumor
Blood-brain barrier(BBB)damage after ischemia significantly influences stroke outcome.Com-pound LFHP-1c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after stroke remains un
Protein arginine methyltransferases(PRMTs)have been implicated in the progression of many diseases.Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery.
Despite considerable progresses in cancer treatment,tumor metastasis is still a thorny issue,which leads to majority of cancer-related deaths.In hematogenous metastasis,the concept of“seed and soil”suggests that the crosstalk between cancer cells(seeds)an
Insulin derivatives such as insulin detemir and insulin degludec are U.S.Food and Drug Administration(FDA)-approved long-acting insulin currently used by millions of people with diabetes.These derivatives are modified in C-terminal B29 lysine to retain in
Multidrug resistance(MDR)mediated by ATP binding cassette subfamily B member 1(ABCB1)is significantly hindering effective cancer chemotherapy.However,currently,no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically,mainly due to the i
Solid tumors are complex entities,comprising a wide variety of malignancies with very different molecular alterations.Despite this,they share a set of characteristics known as“hallmarks of cancer”that can be used as common therapeutic targets.Thus,every t
Nicotinic α4β2 receptor antagonists have drawn increasing attention in the development of new antidepressants.In this study,we aimed to investigate the protective effect of VMY-2-95,the new selective antagonist of α4β2 nicotinic acetylcholine receptor(nAC
The administration of nanoparticles(NPs)first faces the challenges of evading renal filtration and clearance of reticuloendothelial system(RES).After that,NPs infiltrate through the expanded endo-thelial space and penetrated the dense stroma of tumor micr
Proteases have a fundamental role in maintaining physiological homeostasis,but their dysre-gulation results in severe activity imbalance and pathological conditions,including cancer onset,progres-sion,invasion,and metastasis.This striking importance plus