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67个青少年风湿性关节炎患者,用水杨酸治疗,平均随访14.7个月,其目的是为了(1)确定水杨酸的有效剂量;(2)观察临床药物毒性反应的发生率;(3)血清水杨酸的水平与剂量的关系;临床疗效和毒性反应的关系。对水杨酸在血液中的浓度为20—30毫克/100毫升时,疗效与血中药物浓度呈最佳的正相关。超过30毫克/100毫升时疗效未见明显增加。但在56个病人中,有18个病人水杨酸的剂量要大于100毫克/100毫升,才能出现疗效。毒性反应发生率不高,
Sixty-seven adolescents with rheumatoid arthritis were treated with salicylate with an average follow-up of 14.7 months for the purpose of (1) determining the effective dose of salicylic acid; (2) observing the incidence of clinical drug toxicity; (3) Serum salicylic acid levels and dose relationship; clinical efficacy and toxicity of the relationship. Salicylic acid in the blood concentration of 20-30 mg / 100 ml, the efficacy and blood drug concentrations showed the best positive correlation. Over 30 mg / 100 ml no significant increase in efficacy. However, in 56 patients, 18 patients salicylic acid dosage should be greater than 100 mg / 100 ml, in order to appear curative effect. The incidence of toxic reactions is not high,