黑棘皮病合并抗胰岛素糖尿病较为少见,我院于1981年至1987年先后收治4例黑棘皮病合并糖尿病,其中1例血胰岛素水平为160mU/L(μU/ml),红细胞胰岛素受体检查最大特异结合率3.5%(平常9～11%);受体数目下降,亲和力正常,故诊断为胰岛素 Acanthosis nigricans with insulin resistance diabetes mellitus rare in our hospital from 1981 to 1987, has been treated in 4 cases of acanthosis nigricans with diabetes, including 1 case of insulin levels of 160mU / L (μU / ml), the largest examination of red blood cell insulin receptor Specific binding rate of 3.5% (usually 9 to 11%); receptor number decreased, normal affinity, it is diagnosed as insulin