论文部分内容阅读
目的:检测无症状人类免疫缺陷病毒(HIV)感染者血浆细胞因子IL-8、NPI、TNF-α、sIL-2R的浓度,并与健康体检者进行比较,评价无症状HIV感染者的免疫激活状态。方法:选取32例未接受治疗的无症状HIV感染者和22名健康体检者,采用酶联免疫吸附法(ELISA)检测血浆中的IL-8、NPI、TNF-α、sIL-2R浓度,比较二者的差异。结果:与健康体检者比较,无症状HIV感染者的IL-8、NPI、TNF-α、sIL-2R血浆浓度均升高,且有差异(P<0.05)。结论:无症状HIV感染者存在以上述指标为标志的免疫激活状态。
Objective: To detect the levels of plasma cytokines IL-8, NPI, TNF-α and sIL-2R in asymptomatic HIV-infected subjects and evaluate their immune activation as compared with healthy subjects status. Methods: Thirty-two untreated asymptomatic HIV-infected individuals and 22 healthy volunteers were enrolled in this study. Plasma concentrations of IL-8, NPI, TNF-α and sIL-2R were measured by enzyme-linked immunosorbent assay (ELISA) The difference between the two. Results: The plasma levels of IL-8, NPI, TNF-α and sIL-2R in asymptomatic HIV-infected patients were significantly higher than those in healthy controls (P <0.05). Conclusion: Asymptomatic HIV-infected patients have immune activation status marked by the above indexes.