【摘 要】
：
Disulfiram and calcium carbimide are two alcohol deterrents widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports
【机 构】
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Clinical Pharmacology ServiceVirgen de la Victoria University Hospital School of Medicine,Málaga,Spa
【出 处】
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World Journal of Gastroenterology
论文部分内容阅读
Disulfiram and calcium carbimide are two alcohol deterrents widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.
Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here , we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when precribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence clearly needed.
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