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目的观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗职业性黑变病的临床疗效。方法将40例职业性黑变病患者分为2组,对照组21例给予大剂量维生素C、维生素E、六味地黄丸治疗;治疗组19例在对照组的基础上加用还原型谷胱甘肽1.8 g+质量分数为5%葡萄糖溶液250 ml静脉滴注,多烯磷脂酰胆碱10 ml+质量分数为5%葡萄糖溶液250 ml静脉滴注,每日1次。2组疗程均为3个月。以皮肤色素沉着明显变淡、消失或色素沉着面积变小者为有效。结果治疗3个月后,治疗组总体治疗有效率为94.74(18/19),对照组总体治疗有效率为42.86%(9/21),两者比较,差异有统计学意义(P<0.01)。结论在大剂量应用维生素C、维生素E、六味地黄丸的基础上,加用还原型谷胱甘肽联合多烯磷脂酰胆碱治疗职业性黑变病具有较好的临床疗效。
Objective To observe the clinical efficacy of reduced glutathione combined with polyene phosphatidylcholine in the treatment of occupational melanosis. Methods 40 cases of occupational melanosis patients were divided into two groups, the control group of 21 cases given high-dose vitamin C, vitamin E, Liuweidihuangwan treatment; treatment group 19 cases in the control group based on the use of reduced glutathione Peptide 1.8 g + mass fraction of 5% glucose solution 250 ml intravenously, polyene phosphatidylcholine 10 ml + mass fraction of 5% glucose solution 250 ml intravenous infusion, once daily. The two groups were treated for 3 months. To skin pigmentation significantly fades, disappear or pigmentation area smaller effective. Results After 3 months of treatment, the overall treatment effective rate was 94.74 (18/19) in the treatment group and 42.86% (9/21) in the control group. The difference between the two groups was statistically significant (P0.01) . Conclusion The application of reduced glutathione combined with polyene phosphatidylcholine in the treatment of occupational melanosis has a good clinical effect on the basis of high dose of vitamin C, vitamin E and Liu Wei Di Huang Wan.