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目的:探讨新生儿ABO溶血症(ABO-HDN)与O型血母亲抗体效价的相关性。方法:选择712例O型血母亲所产新生儿,对血型为A型、B型的新生儿做ABO-HDN检测,并取其母亲的静脉血进行抗A/B免疫球蛋白G(IgG)效价检测,分析母亲抗IgG效价与ABO-HDN发生率的关系。结果:本组新生儿共检出111例ABO-HDN阳性患儿,ABO-HDN发生率为15.59%(111/712)。ABO-HDN发生率与母亲抗体IgG效价呈正相关(r=0.96,P<0.01);ABO-HDN患儿黄疸出现时间与母亲抗IgG效价无显著相关性(P>0.05)。母亲抗IgG效价≤1∶64组溶血新生儿达到光疗指征率、1周内贫血发生率及换血率均低于其他两组(P<0.05);母亲抗IgG效价≥1∶256组溶血新生儿1周内贫血发生率及换血率高于母亲抗IgG效价1∶128组(P<0.05)。结论:对O型血母亲所产A型或B型血新生儿,早期行溶血三项及抗体效价检查,可预估新生儿发生溶血的可能性及严重程度。
Objective: To investigate the relationship between neonatal ABO hemolytic disease (ABO-HDN) and O-blood mothers antibody titer. Methods: Seventy-two newborns with O-type blood mothers were selected for ABO-HDN detection of neonates with blood type A and B, and their mothers received venous blood for anti-A / B immunoglobulin G (IgG) Titer test to analyze the relationship between maternal IgG titer and ABO-HDN incidence. Results: A total of 111 cases of ABO-HDN positive children were detected in this group. The incidence of ABO-HDN was 15.59% (111/712). The incidence of ABO-HDN was positively correlated with maternal IgG titer (r = 0.96, P <0.01). The incidence of jaundice in children with ABO-HDN was not significantly correlated with maternal anti-IgG titer (P> 0.05). The mothers with anti-IgG titers≤1:64 showed the indication rate of phototherapy in neonates with hemolysis, the rates of anemia and transfusion in one week were lower than those in the other two groups (P <0.05); maternal anti-IgG titer≥1: 256 Hemolytic newborns within 1 week the incidence of anemia and exchange rate higher than the mother anti-IgG titer 1:128 group (P <0.05). CONCLUSIONS: The detection of hemolytic trimester and antibody titer in type A or type B neonates with type O blood mothers can predict the possibility and severity of hemolysis in neonates.