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为了解国产米非司酮对早孕家兔子富收缩及其肌电活动的影响,以及子宫对前列腺索的敏感性变化,同时观察药物终止早孕效果,于动物交配后第9～10天作无菌手术,在一侧子宫肌壁内埋植铂金丝电极,宫腔内安放一橡皮小水囊,通过多导生理记录仪同时记录宫内压及其肌电活动。术后第2天开始灌胃给药,5mg/(kg·d),连续3d。结果给药组子宫活动增强,出现逐渐增强的官缩波及暴发式排放的丛状肌电波,胚胎死亡吸收;相反对照组子宫处于相对静息状态,胚胎继续发育存活。
In order to understand the effect of domestic mifepristone on contractile and myoelectrical activities of pregnant rabbits in early pregnancy, and the sensitivity of uterus to prosthetic cord, and to observe the effect of termination of early pregnancy, the animals were sterilized on the 9th to 10th days after mating Surgery, implantation of platinum wire electrode in the side of the uterine muscle wall, a small rubber balloon placed inside the uterine cavity, recording intrauterine pressure and myoelectrical activity simultaneously through a multi-channel physiology recorder. The first 2 days after the start of intragastric administration, 5mg / (kg · d), continuous 3d. Results The uterus of the administration group was enhanced and the contracted waves and the plexiform EMF of the outbreak were gradually increased. The embryo died and absorbed. On the contrary, the uterus of the control group was in a relative resting state and the embryo continued to develop and survive.