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目的:探讨小细胞肺癌(small cell lung cancer,SCLC)组织中长链非编码RNA外泌体复合物7(long non-coding RNA exocyst complex component 7,Lnc RNA EXOC7)的表达及其临床意义。方法:应用实时荧光定量PCR法检测86例SCLC组织、35例癌旁组织及51例正常肺组织中LncRNA EXOC7的表达,分析LncRNA EXOC7表达与SCLC患者临床病理特征及预后的关系。结果:SCLC组织中LncRNA EXOC7的表达水平明显高于癌旁组织及正常肺组织(P值均<0.001)。LncRNA EXOC7表达与SCLC患者的疾病分期、淋巴结转移、远处转移、化疗疗效及复发有关(P值均<0.05)。高表达LncRNA EXOC7患者的总生存时间及无进展生存时间均短于低表达者(P值均<0.001)。LncRNA EXOC7表达、疾病分期、远处转移及复发是SCLC患者预后的独立影响因素(P值均<0.05)。结论:LncRNA EXOC7参与调节SCLC的发生和发展,可能成为潜在的SCLC患者预后评估的分子标志物。
Objective: To investigate the expression of long non-coding RNA exocyst complex component 7 (LncRNA EXOC7) in small cell lung cancer (SCLC) and its clinical significance. Methods: The expression of LncRNA EXOC7 in 86 SCLC tissues, 35 adjacent tissues and 51 normal lung tissues was detected by real-time fluorescence quantitative PCR. The relationship between LncRNA EXOC7 expression and clinicopathological features and prognosis was analyzed. Results: The expression level of LncRNA EXOC7 in SCLC tissues was significantly higher than that in paracancerous tissues and normal lung tissues (P <0.001). LncRNA EXOC7 expression was associated with disease stage, lymph node metastasis, distant metastasis, chemotherapy efficacy and recurrence in SCLC patients (all P <0.05). Patients with high expression of LncRNA EXOC7 had shorter overall and longer progression-free survival times than those with low expression (P <0.001). The expression of LncRNA EXOC7, disease stage, distant metastasis and recurrence were independent prognostic factors of SCLC (all P <0.05). CONCLUSION: The involvement of LncRNA EXOC7 in the regulation of the development and progression of SCLC may be a potential molecular marker for the prognosis assessment of SCLC patients.