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前列腺癌主要以内分泌疗法为主,但是,一旦内分泌药物治疗有反应或初次治疗发生抗药性、且有50%的病人癌症转移灶有恶化趋势,这是临床治疗中一个重要问题,本文报告、应用顺铂、情来霉素及阿霉素三药联用来治疗转移性前列腺癌,取得良好的效果。对象与方法; 作者近2年来对12例转移性前列腺癌症用上述三种药物进行治疗,年龄均为50～80岁之间,其中有4例病人分别进行过TURP放射性治疗和双侧睾丸切除术,其余8例均属初期治疗,肿瘤分化程度、高分化型5例,中度分化型2例、低分化型5例,12例病人都有骨转移其中1例伴有后腹膜转移、另1例伴有胸膜转移、酸性磷酸酶值12例中有11例增高。
Prostate cancer is mainly based on endocrine therapy. However, once endocrine drug therapy responds or the initial treatment develops drug resistance, and 50% of patients have cancer metastases, this is an important issue in clinical treatment. Cisplatin, elamarycin and adriamycin three drugs were used to treat metastatic prostate cancer and achieved good results. Subjects and Methods; The authors have treated 12 cases of metastatic prostate cancer with the above three drugs in the past 2 years, aged 50 to 80 years old, and 4 of them have undergone TURP radiation therapy and bilateral orchiectomy. The remaining 8 cases were all initial treatments. There were 5 cases of tumor differentiation, well-differentiated type, 2 cases of moderately differentiated type, and 5 cases of poorly differentiated type. 12 cases had bone metastases. One case was associated with retroperitoneal metastasis, and the other 1 Cases with pleural metastases and acid phosphatase values were elevated in 11 out of 12 cases.