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目的:研究癌症患者血浆和组织浸液凝血酶调节蛋白(TM)的浓度变化及其意义。方法:用ELISA法检测188例癌症患者血浆TM和24例癌组织及其邻近正常组织浸液的TM浓度。结果:癌症患者血浆TM水平(33.47±14.25μg/L)明显高于对照组(20.40±7.22μg/L,P<0.01),癌症转移组(41.68±16.96μg/L)明显高于对照组(P<0.01),术后组患者TM(18.45±9.96μg/L)比术前组TM(28.29±11.74μg/L)明显回落(P<0.01),术后复发转移组TM水平(34.50±12.57μg/L)明显增加。癌的类型中,肺癌、胃癌和胰腺癌三种的转移性癌均明显高于各自的非转移性癌(P<0.05—0.01),而非转移的胃癌、胰腺癌、食道癌和喉癌比对照组均无明显差异(P<0.05)。观察癌组织浸液TM(647.71±317.51μg/L)显著低于基邻近正常组织(1455.63±772.22μg/L.P<0.01),而其血浆TM则明显高于对照组。结论:癌症患者血浆TM升高与癌组织的TM表达无关,与癌的扩散转移有关,因此可作为病情进展和转移的一个参考指标。
Objective: To study the changes of plasma and tissue infiltration thrombin regulatory protein (TM) concentrations in cancer patients and its significance. Methods: The concentrations of TM in 188 cases of cancer patients and in 24 cases of cancer tissue and adjacent normal tissues were detected by ELISA. Results: The plasma levels of TM in cancer patients (33.47 ± 14.25μg / L) were significantly higher than those in the control group (20.40 ± 7.22μg / L, P <0.01) and those in the cancer metastasis group (41.68 ± 16.96μg / L) (18.45 ± 9.96μg / L) in postoperative group was significantly lower than that in preoperative group (28.29 ± 11.74μg / L) (P <0.01), but the level of TM in postoperative recurrence and metastasis group was (34.50 ± 12.57) μg / L) significantly increased. Among the types of cancer, the metastatic cancers of lung cancer, gastric cancer and pancreatic cancer were significantly higher than those of the respective non-metastatic cancers (P <0.05-0.01), while those of non-metastatic gastric cancer, pancreatic cancer, esophageal cancer and laryngeal cancer There was no significant difference in the control group (P <0.05). TM (647.71 ± 317.51μg / L) in cancer tissue was significantly lower than that in proximal normal tissue (1455.63 ± 772.22μg / L.P <0.01), while plasma TM was significantly higher than that in control group. Conclusion: The elevated plasma TM in cancer patients has nothing to do with the expression of TM in cancerous tissue, which is related to the spread of cancer. Therefore, it can be used as a reference index for the progression of disease and metastasis.