糖尿病是由多种原因引起的β细胞功能减退,致胰岛素分泌相对或绝对不足引发的糖代谢紊乱,最终导致全身多器官的损害。众所周知,胰岛素的应用虽明显改善了患者的糖代谢紊乱,但无法阻止糖尿病各种并发症的发生及发展,而在体内建立内源性的胰岛素分泌系统才能治愈糖尿病。全胰移植可有效治疗糖尿病,但因其手术创伤大、病死率高、免疫原性大等缺点不再受到人们的青睐,而胰岛移植具有操作简单、创伤小、并发症少等优点,近年来逐渐受到医学界的重视,成为又一新的研究热点。 Diabetes mellitus is caused by a variety of causes of β-cell dysfunction, resulting in the relative or absolute lack of insulin secretion caused by glucose metabolism disorders, eventually leading to multiple body organ damage. As we all know, although the application of insulin has significantly improved the patient’s glucose metabolism disorders, but can not prevent the occurrence and development of various complications of diabetes, and in vivo to establish an endogenous insulin secretion system can cure diabetes. Total pancreas transplantation can effectively treat diabetes, but because of its large trauma, high mortality, immunogenicity and other shortcomings are no longer favored by people, and islet transplantation has the advantages of simple operation, less trauma and fewer complications in recent years Gradually received by the medical community, has become a new research hotspot.