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对海拔4080m地区病毒性肝炎患者的红细胞──超氧化物岐化酶(SOD)和血清丙二醛(MDA)的含量进行了测定,其结果与本地健康人进行了对比,患者SOD含量明显低于对照组(P<0.01),MDA含量明显高于对照组(P<0.01),有非常显著差异。揭示自由基在病毒性肝炎的发病机制中起着重要作用。高原地区病毒性肝炎患者由于长期组织缺氧造成肝细胞进一步损害,使体内氧自由基增多,因此,高原地区在治疗病毒性肝炎时给予自由基清除剂和抗氧化剂是十分有益的。
The levels of erythrocytes superoxide dismutase (SOD) and serum malondialdehyde (MDA) were determined in patients with viral hepatitis at an elevation of 4080m. The results were compared with those of local healthy people, and the SOD level in patients was significantly lower In the control group (P <0.01), MDA content was significantly higher than that in the control group (P <0.01), with significant difference. Reveal that free radicals play an important role in the pathogenesis of viral hepatitis. High altitude areas of patients with viral hepatitis due to long-term tissue hypoxia caused by further damage to liver cells, the body increased oxygen free radicals, so the plateau in the treatment of viral hepatitis given free radical scavenger and antioxidant is very beneficial.