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应用BRDⅡ株26代、28代和31代风疹减毒活疫苗对风疹血凝抑制（HI）抗体阴性的551名1～6岁儿童进行了免疫效果观察。3批疫苗免局42天抗体阳转率分别为98．0％、96.8％和96.4％，抗体GMT分别为115.1、100.9和94．8，表明BRDⅡ株具有良好的免疫原性。3批疫苗的抗体GMT逐年下降，到第3年分别为34、4、36．9和31．2，但各批间差异无显著意义。免后3年，26代和28代疫苗的抗体阳性率仍保持在95％以上，而31代疫苗的抗体阳性率下降至89．2％，明显低于其它两批疫苗。
The immunogenicity of 551 children aged 1-6 years old with rubella hemagglutination inhibition (HI) antibody was observed using the live attenuated live attenuated rubella vaccine of 26th, 28th and 31st generations of BRDⅡ strain. The antibody positive rates of the three batches of vaccines after 42 days were 98.0%, 96.8% and 96.4%, respectively. The GMTs of the three batches of vaccines were 115.1, 100.9 and 94.8, respectively, indicating that the BRDⅡ strain has good immunogenicity. The antibody GMTs of the three batches of vaccines decreased year by year, reaching 34, 4, 36.9 and 31.2 respectively in the third year, but there was no significant difference among the batches. After 3, 26 and 28 generations of vaccine-free antibody positive rate remained above 95%, while the 31-generation antibody antibody positive rate dropped to 89.2%, significantly lower than the other two batches of vaccine.