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目的观察缬沙坦氨氯地平治疗高血压的临床疗效及药物安全性。方法将高血压患者300例随机分为2组各150例。试验组给予缬沙坦氨氯地平片口服,对照组给予缬沙坦胶囊口服。2组均治疗12周,比较2组患者血压变化、临床疗效及安全性。结果治疗前2组患者收缩压、舒张压相比差异均无统计学意义(P>0.05)。治疗后2组收缩压、舒张压均明显下降,且试验组收缩压、舒张压低于对照组,差异均有统计学意义(P<0.05)。试验组总有效率为92.0%高于对照组的80.7%,差异有统计学意义(P<0.05)。试验组不良反应发生率为6.7%,对照组不良反应发生率为10.0%,2组不良反应发生率比较差异无统计学意义(P>0.05)。结论缬沙坦氨氯地平治疗高血压具有安全、高效的降压效果,可在临床治疗中推广使用。
Objective To observe the clinical efficacy and safety of valsartan amlodipine in the treatment of hypertension. Methods 300 cases of hypertensive patients were randomly divided into two groups of 150 cases. The experimental group was given valsartan amlodipine tablets orally, while the control group was given valsartan capsules orally. The two groups were treated for 12 weeks. The changes of blood pressure, clinical efficacy and safety were compared between the two groups. Results Before treatment, there was no significant difference in systolic pressure and diastolic pressure between the two groups (P> 0.05). After treatment, the systolic and diastolic blood pressures were significantly decreased in both groups, and the systolic and diastolic pressures in the experimental group were lower than those in the control group (P <0.05). The total effective rate of the experimental group was 92.0% higher than that of the control group (80.7%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the experimental group was 6.7%, the incidence of adverse reactions in the control group was 10.0%, and there was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Valsartan amlodipine has a safe and effective antihypertensive effect on hypertension, which can be widely used in clinical treatment.