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目的:探讨维生素E在草酸铂引起的周围神经系统毒性中的防治作用。方法:将符合入组条件的32例病人,随机分为两组,A组(17例)接受维生素E 400mg/d治疗+化疗,B组(15例)单纯接受化疗。治疗从接受草酸铂化疗前开始口服,直至草酸铂化疗结束后的3个月。在患者完成8个周期的化疗后评估和统计1、2、3、4级周围神经毒性的发生率。结果:A组1、2、3级的周围神经毒性明显低于B组(P<0.05)。结论:维生素E对草酸铂导致的神经毒性具有神经保护作用,并可作为以草酸铂为基础的化疗病人的补充治疗。
Objective: To investigate the preventive and therapeutic effects of vitamin E on the toxicity of oxaliplatin induced peripheral nervous system. Methods: Thirty-two eligible patients were randomly divided into two groups. Group A (17 patients) received 400 mg / d of vitamin E plus chemotherapy and group B (15 patients) received chemotherapy alone. Treatment was started orally with oxaliplatin chemotherapy until 3 months after oxaliplatin chemotherapy. The incidence of peripheral neurotoxicity in grades 1, 2, 3 and 4 was assessed and counted after the patients completed 8 cycles of chemotherapy. Results: The peripheral neurotoxicity of group A, group 2 and group 3 was significantly lower than that of group B (P <0.05). CONCLUSION: Vitamin E has neuroprotective effects on the neurotoxicity induced by oxaliplatin and may be used as a supplementary treatment for patients treated with oxaliplatin-based chemotherapy.