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Objective:The aim was to study the features and clinical significance of cell apoptosis and proliferation of NK/T cell lymphoma.Methods:TdT-mediated dUTP nick end labeling and immunohistochemical Streptavidin-peroxidase method were used to study cell apoptosis and the expression of proliferation cell nuclear antigen in 25 NK/T cell lymphoma and 10 reactive lymphoid tissues.Results:Apoptotic index(AI) and proliferative index(PI) averaged(1.92%±0.86%) and(41.48%±5.10%) respectively in the 25 NK/T cell lymphomas and(6.70%±1.89%) and(20.10%±2.77%) in the 10 reactive lymphoid tissues.Compared with reactive lymphoid tissues,AI was significantly reduced in NK/T cell lymphoma(t=10.80,P<0.01) while PI significantly increased(t=12.39,P<0.01).In addition,in NK/T cell lymphoma,AI and PI were positively related(r=0.69,P<0.01).Conclusion:In NK/T cell lymphoma,cell apoptosis is reduced while cell proliferation increased.The imbalance between cell apoptosis and cell proliferation is closely related to the development and progression of NK/T cell lymphoma.
Objective: The aim was to study the features and clinical significance of cell apoptosis and proliferation of NK / T cell lymphoma. Methods: TdT-mediated dUTP nick end labeling and immunohistochemical Streptavidin-peroxidase method were used to study cell apoptosis and the expression of proliferation Results: Apoptotic index (AI) and proliferative index (PI) averaged (1.92% ± 0.86%) and (41.48% ± 5.10%) respectively in the 25 NK / T cell lymphomas and (20.70% ± 1.89%) and (20.10% ± 2.77%) in the 10 reactive lymphoid tissues. Compared with reactive lymphoid tissues, AI was significantly reduced in NK / T cell lymphoma 0.01) while PI significantly increased (t = 12.39, P <0.01) .In addition, in NK / T cell lymphoma, AI and PI were positively related , cell apoptosis is reduced while cell proliferation increased. The imbalance between cell apoptosis and cell proliferation is closely relate d to the development and progression of NK / T cell lymphoma.