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目的探讨二期梅毒患者血清中白介素-6(IL-6)、白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)在梅毒发病中的作用,以及与梅毒临床表现、血清抗体滴度之间的关系。方法采用酶联免疫吸附法检测二期梅毒患者血清中IL-6、IL-8及TNF-α水平,同时检测梅毒患者血清抗体滴度,有皮损者常规作皮损病理活检。结果33例二期梅毒患者血清中IL-6、IL-8及TNF-α平均水平均高于正常对照组,两者之间差异有显著性(P<0.001);5例有明显银屑病样皮疹者,病理改变与银屑病极为相似,患者血清快速血浆反应素环状卡片试验滴度均在1∶64以上,IL-6、IL-8及TNF-α水平明显高于其他患者(P<0.001);3例出现吉海反应者,血清IL-6、IL-8、TNF-α亦明显升高,且治疗3周后恢复正常。结论Th1、Th2型细胞因子参与了梅毒感染后机体的病理、生理反应,在二期梅毒皮损形成中起重要作用;这些细胞因子亦参与了吉海反应。
Objective To investigate the role of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the pathogenesis of syphilis in patients with secondary syphilis and their relationship with the clinical manifestations of syphilis, Relationship between antibody titers. Methods Serum levels of IL-6, IL-8 and TNF-α in patients with secondary syphilis were detected by enzyme-linked immunosorbent assay. Serum antibody titers were also detected in patients with syphilis. Skin lesions were routinely biopsied for pathological lesions. Results The mean levels of IL-6, IL-8 and TNF-α in serum of 33 patients with secondary syphilis were significantly higher than those of the normal control group (P <0.001). Five patients had obvious psoriasis Like rashes, pathological changes and psoriasis are very similar to patients with rapid plasma testosterone cyclic card test titers were above 1:64, IL-6, IL-8 and TNF-α levels were significantly higher than other patients ( P <0.001). In 3 cases, there was a significant increase in serum IL-6, IL-8 and TNF-α, and returned to normal after 3 weeks of treatment. Conclusion Th1 and Th2 cytokines play an important role in the pathogenesis and pathophysiology of syphilis infection and play an important role in the formation of secondary syphilis lesions. These cytokines are also involved in the response of the Jihai Sea.