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在日本以至在全世界,亚硝酸盐和硝酸盐都广泛用作食品添加剂,用于加工肉和/或鱼的防腐和发色。最近报道,在各种致突变试验中,亚硝酸钠具有很强的—shima,1980)。同时也已证明亚硝酸钠是N—亚硝基化合物的前体。N—亚硝基化合物对很多种属动物都具有强的致癌活性。动物体内和食品中的硝酸钠可部分地还原为亚硝酸钠(Heisler,Siciliano,Krulick et al.1974;Ishiwata,Boriboon,Nakamuraet al.1975)。但直到目前,尚没有关于这两种化学物质致癌性试验的重要报告。为了弄清这两种化学物的致癌性,因此进行了本研究。
Both nitrites and nitrates are widely used as food additives in Japan and throughout the world for the preservation and color development of processed meat and / or fish. It has recently been reported that sodium nitrite has a strong -shima in various mutagenicity tests, 1980). It has also been demonstrated that sodium nitrite is a precursor of N-nitroso compounds. N-nitroso compounds have strong oncogenic activity on many species of animals. Sodium nitrate in animals and in foodstuffs can be partially reduced to sodium nitrite (Heisler, Siciliano, Krulick et al. 1974; Ishiwata, Boriboon, Nakamura et al. 1975). However, up to now, there are no important reports on the carcinogenicity of these two chemicals. This study was conducted to understand the carcinogenicity of these two chemicals.