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目的：探讨 Th17细胞相关细胞因子IL-17、IL-6、IL-23在类风湿关节炎（rheumatoid arthritis，RA）发病机制中的作用。方法用酶联免疫吸附法检测35例活动组RA患者、35例缓解组 RA 患者及30例健康人血清 IL-17、IL-6、IL-23的水平，并分析它们与活动度和实验室指标的关系。结果RA活动组和缓解组血清IL-23、IL-6水平均明显高于对照组（p<0.05），而RA活动组与缓解租相比，差异亦有统计学意义（p<0.05）。RA 活动组与缓解组血清IL-17水平均高于对照组（p0.05）。RA患者血清IL-17、IL-6和IL-23水平分别与DAS28评分、CRP、ESR， DAS28评分、RF、CRP、ESR和DAS28评分、ESR相关(p＜0.05)。RA患者血清IL-17、IL-6和IL-23水平之间互为正相关关系。结论 Th17细胞相关细胞因子IL-17、IL-6、IL-23均在RA 的发生、发展过程中起着重要作用，并可作为RA活动参考指标。“,”Objective To investigate clinical significances of Th17 related cytokines IL-17, IL-6 and IL-23 in patients with RA. Methods The patients were divided into different groups according to the RA disease activity score (DAS28),35 patients with active RA and 35 patients with inactive RA .Thirty healthy volunteers were recruited as the normal control. Concentrations of serum IL-17, IL-6 and IL-23 were measured by Enzyme linked immunosorbent assay (ELISA).The relationship between Th17 related cytokines and laboratory data were analyzed at the same time. Results Compared with the normal control, the levels of serum IL-23 and IL-6 in patients with RA were significantly increased(p<0.05), and there showed the satatistic differences between patients with active RA and inactive RA(p<0.05). Compared with normal controls, the levels of serum IL-17 in patients with RA were significantly increased, and there showed no statistic differences between patients with inactive RA and normal controls.The levels of serum IL-17, IL-6 and IL-23 were positively correlated with DAS28 Score、CRP、ESR,DAS28 Score、RF、CRP、ESR and DAS28 Score、ESR respectively(p<0.05). Conclusion The results suggest that Th17 related cytokines IL-17, IL-6 and IL-23 may play important roles in the pathogenesis of RA and can be indicators of disease activity.