Shier 等发现一些需2-去氧链霉胺的新霉素、巴龙霉素和 ribostamycin 等氨基糖甙类抗菌素产生菌的变种,于发酵中加入一系列去氧链霉胺的同系物,能生物合成新的氨基糖甙类抗菌素的一种新方法。本文主要报道,需2-去氧链霉胺的 sisomicin产生菌变种的选育和加入一系列2-去氧链霉胺同系 Shier et al. Found that some strains of aminoglycoside-producing bacteria, such as neomycin, paromomycin and ribostamycin, which require 2-deoxy streptomycin, have been added to a series of homologues of deoxystreptamine in fermentation A new method for biosynthesis of new aminoglycoside antibiotics. This article mainly reports that the selection of sisomicin-producing strains requiring 2-deoxy streptomycin and the selection of a series of 2-deoxystransamine homologs