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目的比较复方米非司酮和米非司酮终止早期妊娠的临床疗效。方法将220例停经49d内的正常或合并高危因素妊娠早期妊娠妇女随机分为两组;观察组120例用复方米非司酮(米非司酮30mg+双炔失碳酯5mg)晨1片/d,连服2d,对照组100例用米非司酮晨2片晚1片d,连服2d(共150mg),两组均首次服药后48h加服米索前列醇600μg。观察分析两组完全流产率、孕囊排出时间和流产后阴道出血及服药后的不良反应,了解转经情况。结果复方米非司酮组完全流产率为95.8%,米非司酮组完全流产率为90%,孕囊自行排出时间前者为(2.61±1.68)h,后者为(3.73±1.97)h,出血时间分别(9.2±3.8)h,(14.6±5.8)h,两组比较复方米非司酮完全流产率高于米非司酮组,孕囊排出时间、阴道出血时间及出血量明显低于米非司酮组,服药后不良反应前者稍轻,转经无明显差异。结论复方米非司酮可加速孕囊排出,提高完全流产率,阴道出血时间短,出血量少,且服药方法简单,剂量小,临床疗效优于米非司酮。
Objective To compare the clinical efficacy of mifepristone and mifepristone in terminating early pregnancy. Methods A total of 220 pregnant women with normal or combined risk factors during the first trimester of pregnancy were randomly divided into two groups. In the observation group, 120 cases were treated with compound mifepristone (mifepristone 30mg + anordrin 5mg) d, and even served 2d, the control group of 100 patients with mifepristone morning 2 tablets 1 d, and even served 2d (a total of 150mg), both groups 48h after taking the first dose of misoprostol 600μg. Observation and analysis of two groups of complete abortion rate, gestational sac discharge time and vaginal bleeding after abortion and medication adverse reactions to understand the transfer of the situation. Results The complete miscarriage rate was 95.8% in the mifepristone group, 90% in the mifepristone group, 2.61 ± 1.68 h in the spontaneous gestational sac, and 3.73 ± 1.97 h in the mifepristone group. Bleeding time were (9.2 ± 3.8) h, (14.6 ± 5.8) h, the two groups compared with mifepristone complete abortion rate was higher than the mifepristone group, gestational sac discharge time, vaginal bleeding time and bleeding volume was significantly lower than Mifepristone group, the former adverse reactions after taking a little light, no significant difference between the turn. Conclusion Compound mifepristone can accelerate the discharge of gestational sac, improve the rate of complete abortion, vaginal bleeding time is short, less bleeding, and medication is simple, small dose, the clinical efficacy is superior to mifepristone.