2-氨基-4-三氟甲基-5-甲基-噻吩-3-羧酸乙酯(1)与三苯基膦、六氯乙烷及三乙胺反应,以84%的产率得到膦亚胺2.在碳酸钾的催化下,膦亚胺2与芳基异氰酸酯和双官能亲核试剂的串联氮杂Wittig反应制得新型桥连的双[噻吩并[2,3-d]嘧啶-4(3H)-酮]3,产率为58%～82%.所有产物结构经IR,~1H NMR,MS表征和元素分析确证. Ethyl 2-amino-4-trifluoromethyl-5-methyl-thiophene-3-carboxylate (1) was reacted with triphenylphosphine, hexachloroethane and triethylamine in 84% yield Phosphinimine 2. A series of novel aza-bridged bis [thieno [2,3-d] pyrimidines were prepared by series aza-Wittig reaction of phosphinimine 2 with arylisocyanates and bifunctional nucleophiles under the catalysis of potassium carbonate -4 (3H) -one] 3 in 58% ~ 82% yield.All product structures were confirmed by IR, ~ 1H NMR, MS and elemental analysis.