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目的分析我院126例缺氧性肝炎患者的病因、临床特点及生化指标变化。方法选择2011年6月-2013年10月我院收治的缺氧性肝炎患者126例,调查患者性别、年龄、既往病史、发病诱因等基线资料,分析患者病因、病程、生化指标与变化特点及预后。结果缺氧性肝炎的病因构成主要为急性心力衰竭、脓毒症及严重脓毒症性休克、心脏骤停、心肺复苏术后、肝脏外伤、肝脏及心脏手术后患者,发病年龄(65.9±7.4)岁,生化表现伴有天门冬氨酸氨基转移酶、谷氨酸氨基转移酶、乳酸脱氢酶、肌酸激酶明显升高及总胆红素与间接胆红素升高。患者肝酶及胆酶升高多在发病后48h达到高峰,随着原发病的好转而迅速下降。结论缺氧性肝炎临床发病率高,是临床常见的继发性肝损害,其临床发病特点为起病急,变化快,治疗效果与原发病缺氧诱因的改善密切相关。
Objective To analyze the etiology, clinical features and biochemical changes of 126 cases of hypoxic hepatitis in our hospital. Methods 126 cases of hypoxic hepatitis admitted from June 2011 to October 2013 in our hospital were selected. Baseline data such as sex, age, past medical history and incidence of the disease were investigated. The etiology, course of disease, biochemical indexes and changes of patients were analyzed. Prognosis. Results The main causes of hypoxic hepatitis were acute heart failure, sepsis and severe septic shock, cardiac arrest, cardiopulmonary resuscitation, liver trauma, patients after liver and heart surgery, age of onset (65.9 ± 7.4 ) Years old, biochemical manifestations accompanied by aspartate aminotransferase, glutamate aminotransferase, lactate dehydrogenase, creatine kinase increased significantly and total bilirubin and indirect bilirubin increased. Patients with liver enzymes and bile enzyme increased at 48h after onset peaked, with the improvement of the primary disease and rapidly decline. Conclusions The high incidence of hypoxic hepatitis is a common clinical secondary liver injury. Its clinical features are characterized by acute onset and rapid change. The therapeutic effect is closely related to the improvement of primary hypoxic induction.