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目的分析乙型肝炎病毒(HBV)前S1蛋白与HBV-DNA拷贝数的变化趋势。方法选取医院就诊的300例乙型肝炎表面抗原阳性孕妇,检测HBV前S1蛋白表达情况和HBV-DNA拷贝数,对结果进行分析。结果HBs Ag阳性、e抗原(HBe Ag)阳性、核心抗体(HBc Ab)阳性的患者前S1蛋白阳性率为92.38%。HBs Ag阳性、HBc Ab阳性患者前S1蛋白阳性率为16.15%。随着HBV-DNA拷贝数的增加,前S1蛋白的阳性率亦不断上升,在HBV-DNA拷贝数>108copies/ml时,前S1蛋白的阳性率达到100%。结论前S1蛋白能较好地反映体内的HBV情况,在乙肝五项检测的基础上联合检测前S1蛋白的表达水平,可为低水平HBV感染患者的早期诊断提供参考。
Objective To analyze the change tendency of hepatitis B virus (HBV) pre-S1 protein and HBV-DNA copy number. Methods 300 pregnant women with positive hepatitis B surface antigen (HBsAg) were selected from the hospital for detection of HBV PreS1 protein expression and HBV-DNA copy number, and the results were analyzed. Results The positive rate of pre-S1 protein was 92.38% in patients with HBsAg-positive, HBeAg-positive and HBc-Ab positive. The positive rate of pre-S1 protein in HBsAg-positive patients was 16.15%. With the increase of HBV-DNA copy number, the positive rate of pre-S1 protein is also increasing. The positive rate of pre-S1 protein reaches 100% when the copy number of HBV-DNA> 108 copies / ml. Conclusions The pre-S1 protein can better reflect the HBV status in vivo. Combined detection of the expression of pre-S1 protein on the basis of the five tests of hepatitis B can provide a reference for the early diagnosis of patients with low-level HBV infection.