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本实验通过复制家兔动脉粥样硬化模型,探讨病变程度不同的各主动脉节段上LPLA与胆固醇含量之间的相关关系,同时还测定了血清TC、PHLA、TG及(VLDL+LDL)-Ch水平。实验组主动脉LPLA高于对照组。在病变较严重的节段,LPLA与Ch含量呈正相关,但病变较轻节段和正常主动脉LPLA和Ch不相关。主动脉LPLA的升高与血浆LPLA无关。血清TG和血清TC及(VLDL+LDL)-Ch可分别作为反映生理和动脉粥样硬化病理状态时主动脉LPLA水平的相关指标。本文对动脉LPL的来源及动脉粥样硬化时主动脉LPL升高的机理作了讨论。
In this experiment, the rabbit model of atherosclerosis was replicated to investigate the relationship between LPLA and cholesterol levels in different aortic segments with different lesion levels. Serum TC, PHLA, TG, and (VLDL+LDL) levels were also determined. Ch level. The LPLA of the aorta was higher in the experimental group than in the control group. In the more severely diseased segments, LPLA was positively correlated with Ch, but the lighter segments of the lesions were not associated with LPLA and Ch of the normal aorta. The increase in aortic LPLA was not associated with plasma LPLA. Serum TG and serum TC and (VLDL+LDL)-Ch can be used as relevant indicators of aortic LPLA levels in physiological and atherosclerotic pathological conditions, respectively. This article discusses the source of arterial LPL and the mechanism of aortic LPL elevation during atherosclerosis.