用ENCAPCEL~(TM)微囊技术培养鼠×鼠杂交瘤细胞和生产单克隆抗体,已显示出一定的优越性,表现在最终细胞密度和单克隆抗体产量、浓度以及纯度等四个方面。但鼠杂交瘤不易受人×人杂交瘤,培养方法即选择的限制因素的影响:如维持饲养裸鼠的困难和人×人、人×鼠杂交瘤单克隆抗体产量很低。作者实验应用微囊法培养,研究了生产人×人杂交 Culturing mouse x mouse hybridoma cells and producing monoclonal antibodies with ENCAPCEL ™ microcapsule technology has shown some advantages in terms of final cell density and monoclonal antibody production, concentration and purity. However, hybridomas of mice are not susceptible to human x-hybridomas and the culture method is the choice of limiting factors: the production of monoclonal antibodies to human x-hybridomas is very low, as is the difficulty of maintaining nude mice and human x human. The author experiments using microcapsule culture, the production of human × hybrids