以表面活性剂作为杀精子有效成份的阴道杀精子剂是近年来应用较多、发展较快的一种阴道避孕药物。其特点是毒性低、杀精力强,临床效果较满意。为进一步了解和评价其研究近况,本文对有关文献作一综述。一、表面活性剂作为阴道杀精子剂的研究概况表面活性剂作为阴道杀精子剂的研究是从本世纪才开始的。1931年Barker提出,一些能降低表面张力的物质可以作为良好的杀精剂。此后,相继出现许多有关表面活性剂研究的报道。其中壬苯醇醚(NP-9, Vaginal spermicide with surfactant as the active ingredient of spermicide is a kind of vaginal contraceptive which is applied more and develops rapidly in recent years. It is characterized by low toxicity, strong killing power, clinical results are more satisfactory. In order to further understand and evaluate the current situation of its research, this article reviews the literature. First, the surfactant as a vaginal spermicide research overview Surfactants as vaginal spermicide research is from the beginning of this century. In 1931 Barker suggested that some substances that reduce surface tension can be good spermicides. Since then, there have been many reports of surfactant research. Among them, nonoxynol (NP-9,