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目的为研究高强噪声对豚鼠听功能的影响。方法２４只豚鼠随机分成对照、１１５ｄＢ（Ａ）暴露和１１８ｄＢ（Ａ）暴露三组，每组８只。观察分析了粉红噪声暴露３ｍｉｎ，豚鼠的鼓膜、毛细胞及听力的变化。结果耳镜检查两暴露组鼓膜无明显损伤；但两暴露组都出现了明显的暂时性听阈偏移（ｔｅｍｐｏｒａｒｙｔｈｒｅｓｈｏｌｄｓｈｉｆｔ，ＴＴＳ）；耳蜗铺片观察两暴露组都发现了毛细胞损伤（Ｐ＜０．０１）。两暴露组的ＴＴＳ３０ｍｉｎ内没有恢复到暴露前水平。与１１５ｄＢ（Ａ）暴露组相比，１１８ｄＢ（Ａ）组毛细胞损伤更严重，ＴＴＳ增大更明显（Ｐ＜０．０５）。结论１１５ｄＢ（Ａ）噪声短时间暴露可造成听器损伤
Objective To study the effect of high-intensity noise on auditory function in guinea pigs. Methods Twenty-four guinea pigs were randomized into control, 115 dB (A) exposure and 118 dB (A) exposure in three groups of eight. Observed and analyzed pink noise exposure 3min, guinea pig tympanic membrane, hair cells and hearing changes. Results There was no obvious damage to the tympanic membrane in the two exposed groups by otoscopy. However, both of the two exposed groups showed a significant temporary threshold shift (TTS). Cochlear implants were observed in both exposed groups (P < 0.01). The level of pre-exposure did not return to TTS30min in both groups. Compared with 115 dB (A) exposed group, hair cell damage was more severe in 118 dB (A) group and TTS increased more significantly (P <0.05). Conclusion 115dB (A) Noise Short-term exposure can cause hearing loss