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目的:探讨甲硝唑氯霉素搽剂的有效期。方法:用HPLC法测定甲硝唑氯霉素搽剂中甲硝唑和氯霉素及氯霉素分解产物二醇物的含量,用经典恒温法进行稳定性考察。结果:甲硝唑氯霉素搽剂中的氯霉素含量随温度升高和时间的延长呈线性下降,经典恒温法测得甲硝唑在25℃的贮存期为817d,氯霉素在25℃的贮存期为187d。结论:甲硝唑氯霉素搽剂的有效期暂定为6m。
Objective: To investigate the expiration date of metronidazole chloramphenicol liniment. Methods: The contents of metronidazole, chloramphenicol and chloramphenicol decomposition products in metronidazole chloramphenicol liniment were determined by HPLC. The stability was investigated by classical thermostat method. Results: The concentration of chloramphenicol in metronidazole chloramphenicol liniment decreased linearly with increasing temperature and prolonging of time. The storage period of metronidazole at 25 ℃ was 817d and that of chloramphenicol at 25 ℃ storage period of 187d. Conclusion: Metronidazole chloramphenicol liniment is tentatively scheduled for 6m.