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肝脾肿大型曼氏血吸虫病人,由于肝纤维化及门脉高压而使门脉内大量虫卵栓子通过侧枝循环至肺,常出现严重的肺血管损害,并引起慢性肺源性心脏病。迄目前为止,尚未见有血吸虫病肺部病变经药物治疗后发生变化的报道。本文应用小鼠肺血吸虫病模型,观察了经药物治疗后,对肺血管及实质病变的影响。实验共用雄性瑞士杂种小鼠51只。按Whitaker法结扎门脉,术后约8天,与未结扎对照鼠一样,每鼠由皮下注入曼氏血吸虫尾蚴30条,感染后10周,在大便内查见活卵后,应用羟氨喹及海蒽酮治疗,并设有相应的
Hepatosplenomegaly Schistosoma mansoni patients, due to liver fibrosis and portal hypertension and a large number of intra-portal worm eggs through the collateral circulation to the lungs, often serious pulmonary vascular damage and cause chronic pulmonary heart disease. So far, there have been no reports of changes in the lungs of schistosomiasis after drug treatment. In this paper, the mouse model of pulmonary schistosomiasis was used to observe the effects of the drug on pulmonary vascular and parenchymal lesions. The experiment shared 51 male Swiss hybrid mice. The portal vein was ligated according to the Whitaker method. About 8 days after the operation, 30 mice were injected subcutaneously with Schistosoma mansoni cercariae subcutaneously in the same manner as the control mice without ligation. After 10 weeks of infection, And sea anthrone treatment, and with the corresponding