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以往不少关于慢性肾衰(CRF)残存肾组织的病理形态学研究,主要限于单一时相点的定性描述,尚乏动态的定量研究。我们采用形态计量等方法,观察5/6肾切除所致CRF大鼠残肾形态和功能演变规律及二者的联系,以探讨CRF的共同通道机制。 一、材料与方法 成年雄性Wistar大鼠100只,随机分为A、B两组。A组45只,假手术对照;B组55只,行5/6肾切除[中华肾脏病杂志,1995,11:144]。于术后、30、60、90、120天每组取10只大鼠观察各指
In the past, many studies on the pathological morphology of residual renal tissue in patients with chronic renal failure (CRF) were confined mainly to the qualitative description at a single point in time and lack of dynamic quantitative research. We used morphometry to observe the morphological and functional evolution of CRF remnant kidney caused by 5/6 nephrectomy and their relationship to explore the common channel mechanism of CRF. A, Materials and Methods 100 adult male Wistar rats were randomly divided into A and B groups. A group of 45, sham operation control; B group 55, 5/6 nephrectomy [Chinese Journal of Nephrology, 1995,11: 144]. After surgery, 10, 10, 60, 90, 120 days each group to observe each finger