【摘 要】
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Objective: To assess the therapeutic effect of ulinastatin on severe craniocerebral injuries and to explore its mechanism. Methods: There were 87 cases of sever
【机 构】
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Department of Neurosurgery, Xinhua Hospital Affiliated to Zhejiang Traditional Chinese Medical Colle
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Objective: To assess the therapeutic effect of ulinastatin on severe craniocerebral injuries and to explore its mechanism. Methods: There were 87 cases of severe brain injury in this series and they were either treated by ulinastatin (treatment group, 41 cases) or not (control group, 46 cases) besides routine managements. We estimated C-reactive protein, interleukin-6, superoxide dismutase, and endothelin from plasmas of all the cases on the 1st, 3rd, 5th, and 7th day after injury. Results: C-reactive protein level rose on the 1st and 3rd day after injury in the two groups, but descended in treatment group on the 5th and 7th day and was significantly lower than that in control group (P
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