粒细胞集落刺激因子是一种应用前景广泛的造血生长因子,其cDNA已经克隆并且在哺乳动物细胞和大肠杆菌中均获得表达,有关染色体基因结构业已清楚,但该基因表达调控的深入机制尚待进一步研究。G-CSF受体cDNA也已成功地克隆、表达,进而为深入阐明G-CSF作用分子机理奠定了基础。 Granulocyte colony-stimulating factor is a promising hematopoietic growth factor whose cDNA has been cloned and expressed in both mammalian cells and E. coli. Although the structure of the chromosomal gene has been well understood, the in-depth mechanism of the gene expression regulation remains to be further research. G-CSF receptor cDNA has also been successfully cloned, expressed, and further laid the foundation for further elucidation of the molecular mechanism of G-CSF.