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应用复方苦味叶下珠随机治疗１００例慢性乙型肝炎，并设对照组92例。结果治疗组在疗程结束与停药半年时ＨＢｅ Ａｇ转阴率分别为５８．０％与４９．０％，而其对照组转阴率分别为１３．２％与１１．１％，两组比较有显著差异（P＜０．０５）。此外，治疗组肝功能（HＡ，ＣⅣ）下降幅度，与对照组治疗前后比较，各项亦有显著差异（P＜０．０５）。上述结果表明复方苦味叶下珠具有抑制乙肝病毒复制，改善肝功能和抗肝纤维化等作用。
100 cases of chronic hepatitis B were randomly treated with compound bitter leaves of Phyllanthus and 92 cases in control group. Results In the treatment group, the HBeAg negative rates were 58.0% and 49.0% respectively at the end of the course of treatment and six months after discontinuation, while the negative control rates of the control group were 13.2% and 11.1% respectively. There was a significant difference (P <0.05). In addition, the reduction of liver function (HA, CⅣ) in the treatment group was significantly different from that in the control group before and after treatment (P <0.05). The above results show that Compound Bitter Leaf beads inhibit hepatitis B virus replication, improve liver function and anti-liver fibrosis and so on.