Geothermal water of Xi’an and Xianyang in the central Guanzhong basin is typically geopressured thermal water in China. δ18O and δD data of geopressured thermal water in Xi’an and Xianyang, combined with data from the perimeter of the basin, are analyzed to study features of hydrogen and oxygen shifts. The results show that 18O exchange of geothermal water at the perimeter of the basin and in the non-geopressured thermal water in the center of the basin is not evident, while in most of the geopressured thermal water in the central basin, in cities such as Xi’an and Xianyang, significant oxygen exchange had taken place as well as hydrogen exchange, suggesting that isotope exchanges would slowly move the geothermal water system towards equilib-rium. Thermal water reservoirs in the central basin have passed through significant water-rock reactions. Moreover, the geothermal reservoir of Xianyang city is relatively much more enclosed than that of Xi’an city. It has been observed that the more enclosed the geological environment of geothermal water is, the more obvious the oxygen shifts are. With the increasing of the depth, residence time, total amounts of dissolute solids and temperatures of geothermal waters, the oxygen exchange accelerates. Geothermal water of Xi’an and Xianyang in the central Guanzhong basin is typically geopressured thermal water in China. Δ18O and δD data of geopressured thermal water in Xi’an and Xianyang, combined with data from the perimeter of the basin, are analyzed to study features of hydrogen and oxygen shifts. The results show that 18O exchange of geothermal water at the perimeter of the basin and in the non-geopressured thermal water in the center of the basin is not evident, while in most of the geopressured thermal water in the Central basin, in cities such as Xi’an and Xianyang, significant oxygen exchange had taken place as well as hydrogen exchange, suggesting that isotope exchanges would would move the geothermal water system towards equilibri ri. Thermal water reservoirs in the central basin have passed through, significant water-rock reactions. Moreover, the geothermal reservoir of Xianyang city is relatively much more than than that of Xi’an city. It has been observed that the more enclosed the geological environment of geothermal water is, the more obvious the oxygen shifts are. the increasing of the depth, residence time, total amounts of dissolute solids and temperatures of geothermal waters, the oxygen exchange accelerates.