硒是人体必需的微量元素,已经发现人体中的硒含量与某些疾病有一定的关联。有人认为硒的生物学作用只有以硒氨基酸的形式才能有效发挥。由于含硒氨基酸在人体中含量极微,性质不很稳定,其共存物复杂而又不易分离,因此对微量含硒氨基酸的分析问题基本上没有解决,当然更谈不上探讨它与疾病的关联。1968年K.A.Caldwell等曾用气相色谱法分离硒蛋氨酸和蛋氨酸,硒脱氨酸和脱氨酸,但是其 Selenium is an essential trace element of the human body and it has been found that the selenium content in the human body is associated with certain diseases. Some people think that the biological role of selenium only in the form of selenium amino acids can effectively play. Since the content of selenium-containing amino acids in the human body is extremely small, the nature is not very stable, its complex is not easy to separate the complex, so the analysis of trace selenium-containing amino acids basically no solution, of course, let alone explore its association with the disease . In 1968, K.A. Caldwell et al. Used gas chromatography to separate selenomethionine and methionine, selenocysteine, and tryptophan, but its