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目的 评价复方丹参滴丸对缺血心肌血流灌注的影响。方法 应用复方丹参滴丸治疗冠心病心绞痛 32例 ,并分别于治疗前后进行99mTc MIBISPECT心肌显像 ,应用靶心图进行定量分析 ,对治疗前后的心肌缺血面积 (MIA)进行对比分析。结果 复方丹参滴丸治疗前MIA均值为 32 .6± 7.4% ,治疗后MIA均值为 14.2± 6 .8% ,自身对比有显著差异 (P <0 .0 1)。结论 复方丹参滴丸能明显改善冠心病患者缺血心肌的血流灌注 ,99mTc MIBI SPECT心肌显像的应用为临床心血管药物的疗效研究提供了一条新的途径。
Objective To evaluate the effects of Compound Danshen Dripping Pills on blood flow in ischemic myocardium. Methods Compound Danshen Dripping Pills were used to treat 32 patients with coronary heart disease and angina pectoris. 99mTc MIBI SPECT myocardial imaging was performed before and after treatment. The target heart was used for quantitative analysis. Myocardial ischemic area (MIA) was compared before and after treatment. Results The mean MIA of compound Danshen Dripping Pill before treatment was 32.6±7.4%, and the mean value of MIA after treatment was 14.2±6.6%. There was a significant difference in self-contrast (P < 0.01). Conclusion Compound Danshen Dripping Pills can significantly improve the perfusion of ischemic myocardium in patients with coronary heart disease. The application of 99mTc MIBI SPECT myocardial imaging provides a new approach for the clinical efficacy of cardiovascular drugs.