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目的观察前庭壶腹嵴内电位（ＡＥＰ）对缺血缺氧的反应，以探讨其生理特性的稳定性。方法成年豚鼠４０只，随机分为对照组、缺血组及速尿组。利用高阻抗微电极放大器。观察停止呼吸机造成急性缺氧、阻断颈总动脉造成急性缺血、静脉注射大剂量速尿后ＡＥＰ变化特点。结果正常动物ＡＥＰ为＋４．５５±１．３５ｍＶ，停止呼吸机２ｍｉｎ，ＡＥＰ可下降至２．８±０．８ｍＶ，恢复呼吸后均可观察到超射现象。阻断颈动脉后ＡＥＰ持续下降，达最大负值为－１９．４±１．７ｍＶ，所需时间为５２．５±９．６ｍｉｎ，约１５０ｍｉｎ后缓慢上升至零。静脉注射速尿后观察１８０ｍｉｎ，与注射前比较，无显著性差异。结论ＡＥＰ是一较小的正电位，性质较稳定，对缺氧、缺血及速尿的反应都不同于耳蜗内电位，提示ＡＥＰ可作为反映前庭暗细胞功能状态的指标
Objective To observe the response of the vestibular amputation intracoronary potential (AEP) to ischemia and hypoxia in order to investigate the stability of its physiological characteristics. Methods Forty adult guinea pigs were randomly divided into control group, ischemia group and furosemide group. Utilize high-impedance micro-electrode amplifier. Observe acute respiratory failure caused by hypoxia, block the common carotid artery caused by acute ischemia, high-dose intravenous infusion of AEP after changes in characteristics. Results The AEP of normal animals was + 4.55 ± 1.35mV, the ventilator was stopped for 2min, AEP was decreased to 2.8 ± 0.8mV, and the over shoot phenomenon could be observed after resuscitation. AEP continued to decline after blocking the carotid artery, reaching a maximum negative value of -19.4 ± 1.7mV, the time required for 52.5 ± 9.6min, slowly rising to zero after about 150min. After intravenous furosemide observed 180min, compared with before injection, no significant difference. Conclusions AEP is a small positive potential and more stable in nature. Its response to hypoxia, ischemia and furosemide is different from that of cochlear, suggesting that AEP can be used as an index to reflect the functional status of vestibular dark cells