目的 :研究尖锐湿疣 (CA)角质形成细胞的凋亡及Ki 6 7的表达及其相关性。方法 :对 48例CA采用TUNEL技术原位检测其细胞的凋亡 ,用免疫组化方法 ,观察Ki 6 7阳性的表达。结果 :表皮中见到典型的凋亡细胞 ,表皮各层中有较多Ki 6 7阳性细胞。病情严重度与凋亡指数无显著差异性 (P >0 0 5 ) ;与Ki 6 7阳性细胞指数比较则有显著差异性 (P <0 0 0 5 )。凋亡细胞与Ki 6 7阳性细胞之间呈负相关 (r =0 5 13,P <0 0 5 )。结论 :凋亡在限制病毒的繁殖上起重要作用。Ki 6 7过度表达可能与细胞周期增快有关 Objective: To investigate the apoptosis of keratinocytes and the expression of Ki-67 in condyloma acuminatum (CA) and their correlation. Methods: 48 cases of CA were detected by TUNEL technique in situ cell apoptosis, using immunohistochemical methods to observe the Ki 6 7 positive expression. Results: Apoptotic cells were found in the epidermis. There were more Ki 6 7 positive cells in the epidermis. The severity of the disease was not significantly different from that of the apoptosis index (P> 0.05), but significantly different from the Ki67 positive index (P <0.05). There was a negative correlation between apoptotic cells and Ki67 positive cells (r = 0 5 13, P <0 05). Conclusion: Apoptosis plays an important role in limiting the virus’s reproduction. Ki 6 7 overexpression may be related to increased cell cycle