目的　探讨内窥镜控制下直接经蝶入路切除垂体腺瘤的方法。　方法　 2 2例垂体腺瘤患者 ,在内窥镜控制下 ,经单鼻孔进入 ,术中不切除鼻中隔 ,直接自蝶窦开口打开蝶窦前壁 ,进一步经鞍底切除垂体腺瘤。　结果　 2 2例患者中 ,15例肿瘤全部切除 ,7例肿瘤次全切除。术后随访 1～12个月 ,17例患者内分泌功能恢复正常。 4例术后发生暂时性尿崩症。　结论　内窥镜控制下直接经蝶切除垂体腺瘤入路与目前常规经蝶显微手术比较 ,入路途径较短 ,且安全简捷、损伤小 ,手术显露良好 ,术后反应小 ,值得进一步推广 Objective To investigate the method of endoscopic resection of pituitary adenomas by transsphenoidal approach. Methods Twenty-two patients with pituitary adenoma underwent endoscopic sinus surgery. The nasal septum was excised without endoscopic resection. The anterior wall of the sphenoid sinus was opened directly from the sphenoid sinus and the pituitary adenoma was excised via the sella. Results Of the 22 patients, 15 cases were completely resected and 7 cases were subtotally resected. The patients were followed up for 1 to 12 months. The endocrine function of 17 patients returned to normal. 4 cases of temporary postoperative diabetes insipidus. Conclusions Compared with the conventional transsphenoidal microsurgery, the approach of transsphenoidal resection of pituitary adenoma directly under endoscope is shorter, and it is safe, simple, less damaging, the operation is better and the postoperative reaction is small, so it is worth further promotion