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目的:探讨Survivin和c-erbB-2蛋白在子宫内膜癌表达的相关性及其联合检测的临床意义。方法:应用免疫组化SP法检测原发性子宫内膜癌标本中两种蛋白的表达。结果:(1)子宫内膜癌病例中两者表达具有相关性;(2)两者联合检测敏感性高于单项检测。结论:该两种蛋白在子宫内膜癌的发生、发展中可能起一定的协同作用,并且其联合检测可提高早期预测子宫内膜癌发生的准确性。
Objective: To investigate the correlation between Survivin and c-erbB-2 protein expression in endometrial carcinoma and its clinical significance. Methods: Immunohistochemical SP method was used to detect the expression of two proteins in primary endometrial carcinoma specimens. Results: (1) There was a correlation between the expression of the two in endometrial cancer cases; (2) The combined detection of the two was more sensitive than single detection. Conclusion: The two proteins may play a synergistic role in the occurrence and development of endometrial cancer, and their combined detection can improve the accuracy of early prediction of endometrial cancer.